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Evidence-based research and clinical guides for stress, sleep, and longevity.







Advanced DIM + BioPerine®, Zinc & Niacinamide — daily support for estrogen metabolism, clearer skin, and hormonal balance.*
🛡️ Try it risk-free for 60 days. Not in love with your results? We'll refund you 100%.
Supports healthy estrogen metabolism and hormone balance.
Supports clear, healthy skin and everyday immune defense.
Supports skin health and cellular energy alongside DIM.
Pro Tip: Consistency matters more than dose — take it at the same time every day.
In a self-assessment survey, participants reported real, noticeable changes.
¹ Based on a consumer perception survey of participants after 6 weeks of daily use. ² Post-use satisfaction questionnaire. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Drag the slider to see the difference consistent daily support can make.*
Before
After
Every batch of DIM Complex is formulated to clinically-studied doses, made in a cGMP-certified US facility, and verified by independent third-party labs — so what's on the label is what's in the capsule.
See how 4well DIM Complex compares to a typical drugstore DIM supplement.
DIM · Zinc · Niacinamide — synergistic support for hormone harmony, radiant skin, and daily immunity.
Supports healthy estrogen metabolism and hormonal balance by promoting the favorable 2-hydroxy pathway.
An essential mineral that supports clear, healthy skin, immune defense, and hormonal health.
Supports skin health and cellular energy, complementing DIM and Zinc for a complete daily formula.
"DIM is one of the most researched compounds for supporting healthy estrogen metabolism. Paired with Zinc and Niacinamide at these doses, 4well's formula reflects what the science actually supports."
— The 4well Nutrition Team
Before you buy
A daily capsule providing 370 mg of a diindolylmethane (DIM) blend: DIM 300 mg with zinc 15 mg, niacinamide 50 mg and BioPerine® black pepper extract.
It is formulated to support healthy estrogen metabolism, hormonal balance and skin clarity.* Every active is printed with its own number on the supplement facts panel rather than pooled into a proprietary blend, so the 370 mg on the front is a figure you can break down ingredient by ingredient. BioPerine® is included for absorption rather than as an extra headline name, and the formula is made without artificial colors or sweeteners.
One capsule daily, with a meal and a glass of water.
Food matters here rather than being a nicety: DIM is fat-soluble, so a meal containing some fat is the straightforward way to get more out of the same capsule. Take it at the same time each day, and give it at least 8–12 weeks of uninterrupted use before deciding whether it works for you. Estrogen metabolism moves on a cycle-length timescale rather than a daily one, so two weeks of use tells you very little either way.
DIM 300 mg, zinc 15 mg and niacinamide (vitamin B3) 50 mg, plus BioPerine® black pepper extract — 370 mg in total, in one capsule.
Each of those numbers is printed separately on the supplement facts panel, which is the part worth comparing against other bottles in this category: a single combined figure covering a blend tells you nothing about how much DIM you are actually getting. The 30-day bottle holds 30 capsules, so one bottle is one month at the stated serving. It is made without artificial colors or sweeteners.
Both — DIM supports healthy estrogen metabolism in men and women alike.*
That makes it the exception in our range. Most of what we make is split by biology, because a man in his fifties and a woman in her forties are rarely solving the same problem, and a single unisex bottle usually means one of them is getting a compromise. DIM is different: the pathway is the same one in both. It is formulated for adults of any gender, and it is not intended for anyone under 18, during pregnancy, or while breastfeeding.
Yes — every batch is verified by an independent laboratory for purity and potency.
Manufacturing happens in a cGMP-certified facility in the USA, and the testing is there so that what is on the label is what is in the capsule. Third-party means the lab is not us: we do not grade our own homework on identity, potency or contaminants. If you want the certificate of analysis for the batch you received, email info@4well.com with the lot number printed on your bottle and we will send it to you.
Sixty days from the day your order arrives, and you do not have to send the bottle back.
If the formula is not right for you, email info@4well.com with your order number within that window and we refund you. There is no return shipping to arrange and no requirement that the bottle be unopened: a guarantee that only accepts sealed bottles would be meaningless for a supplement, because you cannot find out whether one suits you without taking it. Refunds are processed within two business days and go back to your original payment method. Cancelling a subscription and requesting a refund are separate actions.
Have questions about third-party testing, dosing, or guarantees?
Explore all 56 questions and direct clinical answers in our comprehensive FAQ Hub.
Build the routine
Chosen for where each one sits in the day, not for anything the combination is said to do.
Metabolic and glucose balance — take with your largest meals.
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Loved By Customers
Published exactly as written by verified 4Well customers.
5 out of 5
I’ve struggled with stubborn hormonal breakouts along my jawline for years that topical creams couldn’t touch. My holistic doctor suggested DIM to help with estrogen metabolism. Within four weeks of taking 4Well DIM daily, the deep cystic flare-ups around my cycle completely calmed down. The addition of zinc and niacinamide has made a visible difference in my skin texture. Truly a game-changer for my skin confidence!
5 out of 5
In my late 40s, perimenopause hit me with erratic moods, bloating, and sudden hot flushes. I wanted a clean, natural solution rather than harsh synthetic alternatives. 4Well's DIM complex has helped smooth out the hormonal rollercoaster. My mood feels far more balanced, the night sweats have eased up significantly, and I don't feel weighed down by fluid retention anymore. One easy capsule a day with lunch—couldn't be simpler.
5 out of 5
My cycles used to come with intense breast tenderness, severe bloating, and heavy fatigue for an entire week beforehand. A nutritionist friend explained that excess estrogen pathways were likely the culprit. Since taking this DIM complex for two months, my PMS symptoms are so mild I barely notice my cycle approaching. I wake up without feeling puffy or inflamed. Highly recommend to any woman dealing with estrogen dominance.
5 out of 5
Transitioning off hormonal birth control left my body in total chaos with rebound oiliness and mood dips. My naturopath recommended DIM with BioPerine for healthy estrogen breakdown. Within 30 days of consistent use, my skin oiliness normalized and my body feels like it's finally back in its natural rhythm. So grateful for this clean, well-formulated product!
5 out of 5
A lot of guys don't realize that men need estrogen balance too, especially over 35 when excess aromatase starts converting testosterone. My trainer recommended a quality DIM supplement. The 370 mg complex here, especially paired with BioPerine for absorption, is top tier. After 5 weeks, I’ve noticed better muscle definition, less stubborn water holding around the midsection, and more steady daily stamina. No digestive upset either.
5 out of 5
I was dealing with chronic sluggishness and brain fog that always peaked during the luteal phase of my cycle. After researching DIM, I chose 4Well because of the 3rd-party testing and transparency. The difference in my overall vitality and mental clarity throughout the entire month has been remarkable. No jitters, no stomach discomfort—just a steady feeling of hormonal equilibrium.
Evidence-based research and clinical guides for stress, sleep, and longevity.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Keep out of reach of children. Discontinue use and seek medical advice if you experience an adverse reaction. Do not exceed the recommended serving.