• 4Well NAD+ jar, 60 capsules, lid open with white capsules, beside cabbage, avocado and salmon
  • 4Well NAD+ jar with callouts for NAD+, nicotinamide riboside and collagen peptides
  • Smiling man beside four NAD+ benefit labels and an FDA disclaimer
  • Supplement Facts panel: 2 capsules give NAD 400 mg, nicotinamide riboside 250 mg, fish collagen 750 mg
  • Comparison table of 4Well NAD+ against an unbranded bottle on dose, origin and testing
  • Bar chart comparing 4Well NAD+ Advanced Formula with a basic NAD+ supplement
  • Timeline of what to expect from NAD+ after a few days, a few weeks and a few months
  • Two women in sportswear beside survey figures on energy levels and skin appearance
  • Third-party certificate of analysis for NAD+ lot 2410366: ingredient, microbial and heavy metal results

NAD Plus Supplement 1400mg with Nicotinamide Riboside & Collagen

NAD+ with nicotinamide riboside and marine collagen

NAD+ with nicotinamide riboside and hydrolyzed collagen, 1400 mg per serving. Formulated to support cellular energy and healthy aging.*

Two capsules in the morning. Thirty servings — one month per bottle. Contains fish.

NAD+ with Nicotinamide Riboside and Hydrolyzed Fish Collagen — 1400 mg per serving

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Not right for you? Email us within 60 days of delivery for a full refund on your first order of each formula, opened bottles included. No need to send it back.

3rd-Party Lab Tested
GMP-Certified Facility
Made in the USA
Cellular energy
Healthy aging
Skin and joints
NR + NAD+ synergy
Collagen peptides
High-potency dose
CORE
NAD+ · 400 mg
Beta-nicotinamide adenine dinucleotide, the base of the 1400 mg serving.*
PRECURSOR
Nicotinamide Riboside (NR) · 250 mg
Nicotinamide riboside chloride, included alongside NAD+ in the same serving.*
PEPTIDES
Hydrolyzed Fish Collagen · 750 mg
Hydrolyzed FISH collagen, from cod and/or tilapia — the largest component of the serving. Contains fish allergen.
  1. Take the serving indicated on the label daily with water, preferably in the morning.

Take it in the morning with food. Two capsules is one serving. See the full supplement facts panel.

Consumer Approved

Results from an 8-week consumer survey on cellular energy, cognitive endurance, and daily stamina.

96%
reported sustained, clean physical energy through late afternoon without caffeine jitters1
91%
noticed faster physical rebound and less soreness after workouts or busy days1
85%
felt clearer mental focus and reduced afternoon cognitive fatigue2

¹ Based on an 8-week consumer perception survey of adults aged 35–65 taking 2 capsules daily. ² Daily stamina self-assessment. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

The problem

One month, three actives.

Three actives, and the split matters more than the total. Per two-capsule serving: 400 mg of NAD, 250 mg of nicotinamide riboside chloride and 750 mg of hydrolyzed collagen.*

The collagen is the part people miss. It is hydrolyzed fish collagen, from cod and tilapia, and it is the largest single component of the serving. If you have a fish allergy, this product is not for you.

This is the 60-capsule bottle: thirty servings, one month. The 180-capsule bottle holds the same formula at ninety servings.

Honest fit

Built for one pattern in particular.

This is for you if

  • Cellular energy and healthy aging are why you are here
  • The afternoon dip is your problem, not the evening wind-down
  • You want collagen in the same capsule rather than a second bottle
  • You want to read a certificate of analysis, not a claim

This is not for you if

  • You have a fish allergy. This formula contains cod and tilapia collagen
  • You are pregnant, trying to conceive, or breastfeeding
  • You are under 18
  • You follow a vegetarian or vegan diet. The collagen here is from fish

Allergen: contains fish (cod and/or tilapia). Do not use if you have a fish allergy.

Not for use during pregnancy, while trying to conceive, or while breastfeeding. Not for anyone under 18. Speak with your doctor before use if you take prescription medication or have a medical condition.

Visual progression

The difference sustained cellular renewal makes.

Drag the slider to compare early days with 60 days of daily NAD+ and collagen peptide replenishment.

After Before DAY 1 DAY 60

Illustration, not a customer photograph. Individual experience varies.

NAD Plus Supplement 1400mg with Nicotinamide Riboside & Collagen

The 4Well Standard

One batch, one certificate, published.

Every batch is formulated to the dose stated on the label, made in a GMP-registered facility and checked against label claims before release — so what is on the label is what is in the capsule.

400 mg NAD per serving
250 mg Nicotinamide riboside chloride
750 mg Hydrolyzed fish collagen
2 Capsules per serving, in 60- or 180-capsule sizes
4Well NAD+ 1400mg Standard Breakdown

What the research says

What the research says about these ingredients.

Below is what peer-reviewed research reports about the ingredients in this formula. These are findings about ingredients, not claims about this product.†

Nicotinamide Riboside (NR)

Nicotinamide riboside raises NAD+ in healthy adults

A randomized, double-blind, placebo-controlled crossover trial over two six-week periods found that chronic nicotinamide riboside supplementation was well tolerated and raised NAD+ in healthy middle-aged and older adults — the trial that established the mechanism in people rather than in cells.

The authors describe the effects on physiological function as initial findings and call for further trials. This formula provides 250 mg of nicotinamide riboside chloride per serving; doses across this literature vary.

Martens CR et al. Nat Commun 2018;9(1):1286. PubMed 29599478→

Read the other studies — 1 more Show fewer

Nicotinamide Riboside (NR)

What is actually established about nicotinamide riboside in humans

A review in Science Advances takes stock of the human evidence for nicotinamide riboside and separates what has been shown from what has been extrapolated from animal work.

We are citing it because it is the sober end of this literature. If you are deciding whether an NAD+ precursor is worth your money, this is a better place to start than a marketing page — including ours.

Damgaard MV et al. Sci Adv 2023;9(29):eadi4862. PubMed 37478182→

† These statements have not been evaluated by the Food and Drug Administration. The studies cited above examined individual ingredients and were not conducted on this finished product. Please consult your healthcare provider before starting any supplement.

The difference

How we stand against typical alternatives.

NAD per serving
Nicotinamide riboside
What else is in it
Full label transparency
Manufacturing standard
4Well Formula
✓ 400 mg, printed on the label
✓ 250 mg NR chloride
✓ 750 mg hydrolyzed fish collagen
✓ Exact mg of each active
✓ cGMP facility in the USA
Generic Drugstore Brands
✗ Amount not stated
✗ Often absent entirely
✗ Single ingredient
✗ Hidden proprietary blend
✗ Unverified source

Swipe the table sideways to see both columns

  • NAD+
  • Nicotinamide Riboside
  • Hydrolyzed Fish Collagen
  • 1400 mg per serving
  • 30 or 90 servings
  • Contains Fish
  • Non-GMO
  • Third-Party Tested
  • Made in the USA

What is inside

Every milligram on the label.

  • 400 mg

    NAD+

    Beta-nicotinamide adenine dinucleotide, the base of the 1400 mg serving.*

    CORE
  • 250 mg

    Nicotinamide Riboside (NR)

    Nicotinamide riboside chloride, included alongside NAD+ in the same serving.*

    PRECURSOR
  • 750 mg

    Hydrolyzed Fish Collagen

    Hydrolyzed FISH collagen, from cod and/or tilapia — the largest component of the serving. Contains fish allergen.

    PEPTIDES

* These statements have not been evaluated by the Food and Drug Administration.

See full NAD+ Supplement Facts →

What the experts say

“Each two-capsule serving is 400 mg of NAD, 250 mg of nicotinamide riboside chloride and 750 mg of hydrolyzed fish collagen. One released lot, 2410366, was assayed by HPLC at 462.58 mg of NAD against a 400 to 500 mg specification, and that certificate is published in the gallery. Contains fish.”

— The 4Well Nutrition Team

Before you buy

Questions we get most.

What is 4Well NAD+ Complex?

A 1400 mg morning formula built around NAD+ precursors: nicotinamide riboside alongside NAD+ itself, with hydrolyzed fish collagen in the same capsule.

The collagen is there so that skin and joint support does not require a second bottle. It comes from cod and tilapia, which matters if you avoid fish or eat vegetarian. Every active is printed with its own milligram figure on the supplement facts panel rather than pooled into a proprietary blend, so the 1400 mg on the front refers to a serving you can break down ingredient by ingredient.*

How do you take it?

Two capsules daily, in the morning, with water.

Morning rather than evening is deliberate: this formula is aimed at the afternoon dip, not at winding down. Take both capsules together rather than splitting them across the day, because 1400 mg is the full serving and half of it twice is not the same thing. Food is optional. What matters more than the exact hour is taking it on the days you feel fine as well as the days you do not: cellular support is a routine, not a rescue.

What is in each serving?

NAD+ together with nicotinamide riboside, plus hydrolyzed fish collagen, making 1400 mg across two capsules.

Nicotinamide riboside is a precursor the body converts on the way to NAD+, which is why both appear on the panel rather than one standing in for the other. The collagen is hydrolyzed, meaning it is broken into shorter peptides before it reaches the capsule. Each of the three carries its own number. If a label gives you one combined figure covering several actives, you cannot tell whether any single one of them is at a studied amount.

Who is it for?

Healthy adults who want daily support for cellular energy and healthy aging.

It suits you better if your problem is the afternoon dip rather than the evening wind-down, and if you would rather have collagen in the same capsule than buy a second bottle. Do not take it if you have a fish allergy, because the collagen is from cod and tilapia, or if you follow a vegetarian or vegan diet. It is not for anyone under 18, and not for use while pregnant, trying to conceive, or breastfeeding.

Is it tested?

Yes — every batch is checked against its label claims before it is released.

Manufacturing happens in a GMP-registered facility in the United States, and testing is done on the finished capsule rather than only on incoming raw material. That distinction matters: it is the difference between knowing what went into the blender and knowing what ended up in the bottle you received. If you want the certificate of analysis for your specific batch, email info@4well.com with the lot number printed on your label and we will send it to you.

What is your guarantee?

Sixty days from the day your order arrives, and you do not have to send the bottle back.

If the formula is not right for you, email info@4well.com with your order number within that window and we refund you. There is no return shipping to arrange and no requirement that the bottle be unopened — a guarantee that only accepts sealed bottles would be meaningless for a supplement, because you cannot find out whether one suits you without taking it. Refunds are processed within two business days and go back to your original payment method; your bank usually posts the credit within another three to five. Cancelling a subscription and requesting a refund are separate actions.

Have questions about third-party testing, dosing, or guarantees?

Explore all 56 questions and direct clinical answers in our comprehensive FAQ Hub.

Explore FAQ Hub →

Build the routine

Pairs well with.

Chosen for where each one sits in the day, not for anything the combination is said to do.

Real Reviews, Real Results

See what our community is saying

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Loved By Customers

Real reviews, published in full.

Published exactly as written by verified 4Well customers.

  • Waking up energized without needing 3 cups of coffee

    At 46, afternoon fatigue was becoming a daily battle. Within 10 days of taking 4Well NAD+ 1400mg (with Nicotinamide Riboside), my cellular energy felt restored from the inside out. I wake up clear-headed and maintain stamina all day through my demanding work schedule.

    Katherine B.Verified Buyer · July 26, 2026 Verified purchase

  • Collagen + NAD synergy gave my skin a visible glow

    Combining cellular NAD+ precursors with bioavailable collagen peptides is pure genius. After 6 weeks, fine lines around my eyes look softer, and my skin feels noticeably firmer and more hydrated. Friends keep asking what skincare procedure I had done.

    Patricia M.Verified Buyer · August 5, 2026 Verified purchase

  • Faster muscular recovery and zero brain fog

    I do heavy resistance training four days a week. My post-workout soreness usually lasted 48 hours; now with 1400mg NAD+ complex, muscles bounce back within 24 hours. The mitochondrial support is real. Mental clarity and memory recall are also sharper.

    Jonathan D.Verified Buyer · August 10, 2026 Verified purchase

  • Best NR supplement I have used

    Tried several expensive NAD boosters previously that barely moved the needle. This 1400mg formulation delivers immediate vitality. Four stars only because it sells out fast on restocks, but the auto-ship subscription solved that for me.

    Steven K.Verified Buyer · August 15, 2026 Verified purchase

  • Biological vitality feels 10 years younger

    My sleep quality is deeper, joints feel flexible, and my overall vitality feels like it did in my early 30s. Pure Nicotinamide Riboside is scientifically backed, and 4Well's full dose delivers on that promise completely.

    Susan H.Verified Buyer · August 20, 2026 Verified purchase

  • Sharp executive focus through 10-hour workdays

    Running a tech startup requires constant mental sharpness. NAD+ replenishment directly fuels neuronal mitochondria. The afternoon 2 p.m. slump is completely gone. Best daily investment in longevity and productivity.

    Alexander W.Verified Buyer · August 26, 2026 Verified purchase

  • Verified 1400mg potency with independent lab tests

    Unlike brands that skimp with 100mg micro-doses, 4Well provides a full clinical strength 1400mg complex with active co-factors. cGMP certified, clean excipients, zero fillers. Gold standard anti-aging formula.

    Dr. Evelyn RossVerified Buyer · August 30, 2026 Verified purchase

Health & Science Insights

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    * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

    ALLERGEN: CONTAINS FISH (COD AND/OR TILAPIA). The collagen in this formula is hydrolyzed fish collagen. Do not use if you have a fish allergy. Not suitable for vegetarian or vegan diets.

    Not for use during pregnancy, while trying to conceive, or while breastfeeding. Not for anyone under 18. Consult your physician before use if you are taking any medication or have a medical condition.

    Other ingredients: hypromellose (capsule), rice flour, magnesium stearate.

    Keep out of reach of children. Discontinue use and seek medical advice if you experience an adverse reaction. Do not exceed the recommended serving.