---
type: Guide
title: "DIM Supplements: Estrogen Metabolism, Dosage and How to Choose One"
description: "DIM shifts which estrogen metabolites the body makes."
resource: "https://4well.com/blogs/news/dim-supplement-benefits-dosage-guide"
tags: [hormones, guide, evidence]
timestamp: 2026-09-17T00:00:00Z
---

# DIM Supplements: Estrogen Metabolism, Dosage and How to Choose One

DIM shifts which estrogen metabolites the body makes. The widely quoted 47% rise in the 2/16α ratio missed significance (PMID 15623462); the stronger evidence is 130 women over twelve months (PMID 28560655), which also recorded lower tamoxifen metabolites in the DIM arm.

- Published: 2026-09-03
- Read: https://4well.com/blogs/news/dim-supplement-benefits-dosage-guide
- Every trial in the guide links to its PubMed record; the guide ends with a References list and the same set is exposed as `citation[]` in its BlogPosting markup.
- Trials cited above: [PMID 15623462](https://pubmed.ncbi.nlm.nih.gov/15623462/), [PMID 28560655](https://pubmed.ncbi.nlm.nih.gov/28560655/)

## Related

- Topic: [Hormones](okf-topics-hormones.md)
- Formula discussed on the site for this topic: [DIM Complex 370 mg](okf-products-dim-complex-370-mg.md)

## Source

Summary written from the published guide (reviewed 2026-09-17). Guides are written by the formulation team from human trials; every dose claim links to its PubMed record; mixed and negative results are included; there is no clinician review and nothing on the site is medical advice.